Research Scientist I, CDoT

Embedded within the Broad Institute of Harvard and MIT, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate the deep biological insights emerging from the Broad community into new therapeutics. To accomplish this mission, we partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry professionals in pharmaceutical, biotechnology and venture capital firms and advance cutting-edge drug discovery projects. We create new technologies and work to apply the unique capabilities of the Broad Institute to enable new therapeutic approaches that will broadly benefit the scientific community. We are seeking a highly motivated and capable Research Scientist I to join the Biochemistry & Biophysics group. As a lab-based position, the candidate will be responsible for the development, implementation and execution of biochemical and biophysical assays utilizing state-of-the-art capabilities to advance drug discovery projects, and experience in this area is required. Responsibilities: • Lead the development and execution of biochemical and biophysical assays to support hit identification, validation, and lead optimization (e.g., SPR, BLI, FP, TR-FRET) • Characterize recombinant proteins and their interactions using biochemical and biophysical assays (e.g., DSF, ITC, MST, and NMR) • Design and execute research plans to ensure that critical project requirements, timelines and deliverables are met • Investigate and implement new methods for emerging group technologies • Serve as a member of cross-functional project teams, interpreting and communicating results in a clear and concise manner to academic and industry partners • Troubleshoot and solve scientific problems independently • Operate and maintain lab equipment independently • Maintain detailed records of lab experiments using a digital notebook (ELN) Qualifications: • Ph.D. in Biochemistry, Biophysics, Structural biology or related life science field with 0-2+ years of relevant lab experience or a Master's education in Biochemistry, Biophysics, Structural biology with 7+ years of relevant experience • Biochemical and biophysical assay development experience, with an advanced understanding of protein biochemistry and biophysics • Significant experience with bioanalytical instrumentation and techniques, including SPR, BLI, ITC, MST, and/or NMR • Experience in biophysical characterization of biologics (e.g., antibodies, nanobodies, bispecifics) is beneficial, but not required. The successful candidate will be a results-focused, team-oriented, creative bench scientist. He or she must be self-motivated and detail-oriented, exhibiting strong problem-solving skills and the ability to excel in a fast-track environment. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with cross-functional project teams in identifying and achieving research goals.