Advanced Integrated Wet-Lab and Computational Reseacher, Levi Lab

%3Cp%3E%3Cstrong%3EComputational Biologist II, Advanced Integrated Wet-Lab and Computational Researcher, Levi Lab%3C/strong%3E%3C/p%3E%3Cp%3E%3Cstrong%3EWHY UT SOUTHWESTERN?%3C/strong%3E%3Cbr%3EWith over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to %3Ca href=%22https://www.utsouthwestern.edu/newsroom/articles/year-2022/july-us-news-best-hospital.html%22 target=%22_blank%22%3EU.S. News %26amp; World Report%3C/a%3E, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you%27ll discover a culture of teamwork, professionalism, and a rewarding career!%26nbsp;%3Cbr%3E%3Cbr%3E%3Cstrong%3EJOB SUMMARY%3C/strong%3E%3Cbr%3EPerform professional work in support of scientific research using technical knowledge of software, software development, networking, and/or hardware in a complex computing environment. Subject matter expert in multiple areas of computing technology, and specific knowledge of molecular biology and genetics. Work collaboratively with Principal Investigator (%22PI%22) to determine the most suitable computational methods and tools to analyze large-scale biological data sets. Prepare reports for presentation or publication. Responsible for assisting PI in meeting the system needs for multiple research projects and/or labs.%26nbsp;%3Cbr%3E%3Cbr%3EThis position is designed for an advanced scientist who can bridge wet-lab experimentation and independent computational analysis. The Computational Biologist II will help lead mechanistic and translational studies of injury, fibrosis, regeneration, aberrant mesenchymal cell fate, wound healing, tumor biology, and therapeutic response. The individual will work from study design and sample generation through data preprocessing, integration, biological interpretation, validation, and publication.%3C/p%3E%3Cp%3ELEVI LABORATORY RESEARCH PROGRAM%3C/p%3E%3Cp%3EThe Levi Laboratory studies how immune, stromal, vascular, lymphatic, neural, epithelial, and mesenchymal cell populations interact after injury and in disease. The laboratory integrates transgenic and surgical animal models, human biospecimens, molecular and cellular biology, quantitative imaging, and multiomic technologies to identify mechanisms and therapies that promote faithful tissue repair.%3C/p%3E%3Cul%3E%3Cli%3ETraumatic heterotopic ossification and aberrant mesenchymal differentiation after burns, musculoskeletal trauma, surgery, and tendon injury.%3C/li%3E%3Cli%3EFibrosis, wound healing, burn and scar biology, including inflammatory and epigenetic regulation of keratinocyte, fibroblast, immune, and progenitor-cell function.%3C/li%3E%3Cli%3ETendon, muscle, bone, and soft-tissue repair, including mechanotransduction, extracellular matrix remodeling, and stem or progenitor-cell fate.%3C/li%3E%3Cli%3ENeurovascular and neuroimmune regulation of regeneration, tendinopathy, heterotopic ossification, pain, and osteosarcoma, and adrenergic signaling.%3C/li%3E%3Cli%3ELymphatic regulation of inflammation, tissue repair, and bone resorption, including VEGF-C or VEGF-D signaling and lymphatic endothelial-cell biology.%3C/li%3E%3Cli%3EImmunometabolism and obesity-related injury responses, including lipid metabolism, inflammatory signaling, and altered regenerative cell states.%3C/li%3E%3Cli%3ECirculating mesenchymal progenitor cells and liquid-biopsy approaches for early diagnosis, risk prediction, and treatment monitoring.%3C/li%3E%3Cli%3ECancer biology and osteosarcoma, including tumor heterogeneity, tumor microenvironment interactions, angiogenesis, pain, drug response, and pulmonary metastasis.%3C/li%3E%3C/ul%3E%3Cp%3EESSENTIAL JOB DUTIES%3C/p%3E%3Cul%3E%3Cli%3EDesign integrated experimental and computational strategies with the PI, clinical collaborators, and laboratory scientists, including sample selection, controls, replication, power considerations, batch mitigation, and validation plans.%3C/li%3E%3Cli%3EIndependently analyze scRNA-seq, snRNA-seq, bulk RNA-seq, snATAC-seq or other epigenomic data, spatial transcriptomic data, proteomic and metabolomic data, CyTOF or high-parameter flow data, and quantitative imaging datasets from raw files through biological interpretation.%3C/li%3E%3Cli%3EPerform quality control, normalization, batch correction, cell-type annotation, differential analysis, pathway enrichment, trajectory and pseudotime analysis, gene-regulatory network inference, cell-cell communication modeling, ligand-receptor analysis, and cross-modality integration.%3C/li%3E%3Cli%3EDevelop spatial and image-computational workflows for immunofluorescence, histology, multiplex imaging, micro-CT, confocal or whole-slide microscopy, and three-dimensional tissue datasets.%3C/li%3E%3Cli%3EIntegrate experimental data with clinical variables, longitudinal outcomes, public datasets, and large multiomic databases to identify biomarkers, mechanisms, and therapeutic targets.%3C/li%3E%3Cli%3EDevelop and rigorously evaluate statistical and machine-learning models for disease classification, early detection, risk prediction, treatment response, and biomarker prioritization, with appropriate feature selection, cross-validation, calibration, and external or biological validation.%3C/li%3E%3Cli%3EBuild, document, test, and maintain reproducible analysis pipelines in R and Python using version control, workflow management, containerized environments, and high-performance or cloud computing resources.%3C/li%3E%3Cli%3EEstablish laboratory standards for metadata, data dictionaries, sample tracking, file organization, quality metrics, code review, backup, controlled access, and FAIR data practices while complying with institutional and sponsor requirements.%3C/li%3E%3Cli%3EPerform or directly support wet-lab studies required to generate and validate computational findings, including animal handling, tissue harvest, cell and tissue dissociation, histology, immunostaining, imaging, cell culture, flow cytometry, nucleic acid isolation, PCR or qPCR, and sequencing-library workflows.%3C/li%3E%3Cli%3ESupport transgenic colony studies, lineage-tracing experiments, injury and disease models, therapeutic perturbations, and collection of blood, skin, tendon, muscle, bone, tumor, lymphatic, and metastatic tissues.%3C/li%3E%3Cli%3ETranslate computational hypotheses into targeted validation experiments using molecular assays, immunohistochemistry, CRISPR-Cas9 or other gene perturbation approaches, pharmacologic studies, and functional cellular or animal assays in collaboration with experimental scientists.%3C/li%3E%3Cli%3EGenerate publication-quality visualizations and clear data narratives; lead computational sections of manuscripts, abstracts, grants, progress reports, and presentations; and contribute to high-impact peer-reviewed publications.%3C/li%3E%3Cli%3EPresent findings at laboratory meetings and national or international scientific forums, communicate limitations and uncertainty clearly, and respond constructively to scientific review.%3C/li%3E%3Cli%3EMentor trainees and staff in computational biology, experimental design, statistics, reproducible research, and biological interpretation, while contributing to a respectful, inclusive, and accountable laboratory culture.%3C/li%3E%3C/ul%3E%3Cp%3ESTRONGLY PREFERRED TECHNICAL EXPERTISE%3C/p%3E%3Cul%3E%3Cli%3EAdvanced proficiency in R and Python for biological data analysis, statistics, visualization, and pipeline development; experience with Linux, shell scripting, Git, and high-performance computing.%3C/li%3E%3Cli%3EDemonstrated hands-on experience analyzing single-cell transcriptomic datasets independently from raw-data processing and quality control through cell annotation, mechanistic interpretation, figure generation, and validation.%3C/li%3E%3Cli%3EExperience with spatial transcriptomics and at least one additional high-dimensional modality such as metabolomics, proteomics, epigenomics, CyTOF, imaging mass cytometry, or multiplex tissue imaging.%3C/li%3E%3Cli%3EExperience managing and integrating large clinical, imaging, or multiomic databases with robust metadata, reproducible provenance, and appropriate privacy and access controls.%3C/li%3E%3Cli%3EStrong foundation in molecular and cell biology, genetics, cancer or musculoskeletal biology, immunology, developmental biology, regenerative medicine, or a related field.%3C/li%3E%3Cli%3EPractical wet-lab experience with mammalian cell culture, animal handling, tissue processing, embedding, sectioning and staining, immunofluorescence or immunohistochemistry, microscopy, molecular assays, and sample preparation for sequencing or other omic platforms.%3C/li%3E%3Cli%3EAbility to choose appropriate statistical methods, recognize confounding and batch effects, distinguish exploratory from confirmatory analyses, and communicate uncertainty without overinterpreting results.%3C/li%3E%3C/ul%3E%3Cp%3EPREFERRED DOMAIN AND METHODOLOGICAL EXPERIENCE%3C/p%3E%3Cul%3E%3Cli%3EMesenchymal progenitor and stem-cell biology, lineage tracing, aberrant cell fate, osteogenesis, chondrogenesis, fibrosis, wound repair, or extracellular matrix biology.%3C/li%3E%3Cli%3E%26nbsp;Immune-stromal, neurovascular, lymphatic, or tumor microenvironment analysis, including macrophage states, endothelial populations, sensory and sympathetic nerves, and cell-cell signaling.%3C/li%3E%3Cli%3EMouse models of burn and musculoskeletal injury, heterotopic ossification, tendon degeneration, obesity or metabolic disease, wound healing, cancer, or metastasis.%3C/li%3E%3Cli%3EHuman translational studies using biospecimens, circulating rare-cell populations, biomarker discovery, diagnostic modeling, or longitudinal clinical outcomes.%3C/li%3E%3Cli%3ETools such as Seurat, Scanpy, Bioconductor, Signac, ArchR, Cell Ranger, Space Ranger, Harmony, scVI, Monocle, Slingshot, CellChat, NicheNet, SCENIC, DESeq2, edgeR, limma, or equivalent platforms.%3C/li%3E%3Cli%3EQuantitative imaging and pathology tools such as QuPath, ImageJ or Fiji, CellProfiler, HALO, Imaris, or custom computer-vision workflows.%3C/li%3E%3Cli%3ESCIENTIFIC LEADERSHIP AND PROFESSIONAL COMPETENCIES%3C/li%3E%3Cli%3EAbility to manage several projects, set priorities, document decisions, meet deadlines, and move analyses from exploratory work to publication-quality completion.%3C/li%3E%3Cli%3EExcellent critical thinking, troubleshooting, scientific writing, oral communication, collaboration, and project-management skills.%3C/li%3E%3Cli%3EAbility to explain computational concepts to experimental and clinical collaborators and translate biological questions into rigorous analytic plans.%3C/li%3E%3Cli%3ECommitment to research integrity, reproducibility, responsible authorship, data stewardship, laboratory safety, continuous learning, and sustained engagement with both bench and computational work rather than functioning exclusively as a data-analysis service.%3C/li%3E%3C/ul%3E%3Cp%3E%3Cstrong%3EBENEFITS%3C/strong%3E%3Cbr%3EUT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:%3C/p%3E%3Cul%3E%3Cli%3EPPO medical plan, available day one at no cost for full-time employee-only coverage%3C/li%3E%3Cli%3E100% coverage for preventive healthcare-no copay%3C/li%3E%3Cli%3EPaid Time Off, available day one%3C/li%3E%3Cli%3ERetirement Programs through the Teacher Retirement System of Texas (TRS)%3C/li%3E%3Cli%3EPaid Parental Leave Benefit%3C/li%3E%3Cli%3EWellness programs%3C/li%3E%3Cli%3ETuition Reimbursement%3C/li%3E%3Cli%3EPublic Service Loan Forgiveness (PSLF) Qualified Employer%3C/li%3E%3Cli%3E%3Ca href=%22http://jobs.utsouthwestern.edu/benefits/#top%22 target=%22_blank%22%3ELearn more about these and other UTSW employee benefits!%3C/a%3E%3C/li%3E%3C/ul%3E%3Cp%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3EEXPERIENCE AND EDUCATION%3C/strong%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3ERequired%3C/strong%3E%3C/p%3E%3Cul%3E%3Cli%3E%3Cstrong%3EEducation%3C/strong%3E%3Cbr%3EPhD in Computer Science or a related field of biological science, with thesis work in bioinformatics and computational biology or%26nbsp;%3Cbr%3EMaster%27s Degree in Computer Science or a related field of biological science or%26nbsp;%3Cbr%3EBachelor%27s Degree in Computer Science or a related field of biological science%26nbsp;%3Cbr%3E%26nbsp;%3C/li%3E%3C/ul%3E%3Cul%3E%3Cli%3E%3Cstrong%3EExperience%3C/strong%3E%3Cbr%3E2 years of related research experience in bioinformatics and computational biology with Master%27s Degree or%26nbsp;%3Cbr%3E4 years of related research experience in bioinformatics and computational biology with Bachelor%27s Degree.%26nbsp;%3Cbr%3E%26nbsp;%3C/li%3E%3C/ul%3E%3Cp%3E%3Cbr%3E%3Cstrong%3EJOB DUTIES%3C/strong%3E%3C/p%3E%3Cul%3E%3Cli%3EManage computer hardware and software programming and maintenance for one or more research laboratories. Ensure existing systems meet the continuing needs of the labs and/or recommend and test new systems as necessary.%3C/li%3E%3Cli%3EPerform or direct others to perform complex data analysis related to specialized research methodologies and results. Manage assigned research projects with minimal input from PI.%3C/li%3E%3Cli%3EDevelop and/or modify software to support new and ongoing research projects.%3C/li%3E%3Cli%3EResolve hardware, software, and network issues in support of the lab.%3C/li%3E%3Cli%3EOversee the development and maintenance of complex databases to support new and ongoing research projects.%3C/li%3E%3Cli%3EPrepare research reports for presentation, and assist with preparation of manuscripts for publication.%3C/li%3E%3Cli%3EMay specialize in bioinformatics, software development, network administration, or hardware/software maintenance.%3C/li%3E%3Cli%3EPerform other duties as assigned.%3C/li%3E%3C/ul%3E%3Cp%3E%3Cstrong%3ESECURITY AND EEO STATEMENT%3C/strong%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3ESecurity%3C/strong%3E%3Cbr%3EThis position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information.%3Cbr%3E%3Cbr%3E%3Cstrong%3EEEO%3C/strong%3E%3Cbr%3EUT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.%3Cbr%3E%26nbsp;%3C/p%3E

Job Details
Primary Location: Texas-Dallas-5323 Harry Hines Blvd
Work Locations: 5323 Harry Hines Blvd, Dallas, 75390
Job: Research & Laboratory
Organization: 364007 - MD-Lab B Levi
Schedule: Full-time
Shift: Day Job
Employee Status: Regular
Job Type: Standard
Job Posting: Sep 4, 2026, 5:39:05 PM