Computational Research Scientist, Simmons Cancer Center

%3Cp%3E%3Cstrong%3EWHY UT SOUTHWESTERN?%3C/strong%3E%3Cbr%3EWith over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to %3Ca href=%22https://www.utsouthwestern.edu/newsroom/articles/year-2022/july-us-news-best-hospital.html%22 target=%22_blank%22%3EU.S. News %26amp; World Report%3C/a%3E, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you%27ll discover a culture of teamwork, professionalism, and a rewarding career!%26nbsp;%3Cbr%3E%3Cbr%3E%3Cstrong%3EJOB SUMMARY%3C/strong%3E%3Cbr%3ELeads the design and implementation of High-Performance Scientific Computing infrastructure. Performs and supports scientific research using technical knowledge of software, software development, complex databases, high-performance computing, and/or hardware in a complex computing environment. Performs scientific research using knowledge of formalisms and algorithms from mathematics, statistics, and/or computer science.%26nbsp;%3C/p%3E%3Cp%3EThe Center for Cellular Therapies and Cancer Immunology in the Harold C. Simmons Comprehensive Cancer Center is looking to hire a Computational Research Scientist at the interface of machine learning, cancer genomics, and immunology. You will build and apply computational methods that turn large-scale multi-omic and functional datasets into validated therapeutic hypotheses, while working side by side with experimental and translational scientists to bring those hypotheses to the clinic.%3C/p%3E%3Cp%3EThis is a senior, high-autonomy position suited to someone who wants their models to drive biological discovery to therapies. You will help set scientific direction, mentor junior computational and experimental scientists, and serve as the analytical backbone of a program developing novel immunotherapies within a new center.%3C/p%3E%3Cp%3E%3Cbr%3E%3Cstrong%3EWhat you will do%3C/strong%3E%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Build predictive models that integrate genomic, transcriptomic, epigenomic, single-cell, and functional-screen data to nominate novel therapeutic targets in cancer and the tumor immune microenvironment.%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Drive immunotherapy engineering by applying machine learning to antigen and neoantigen discovery, de novo protein design, and the optimization of engineered immune cells.%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Develop methods for interpreting high-dimensional and perturbation data, including deep learning approaches to sequence, structure, and single-cell readouts.%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Partner closely with wet-lab scientists to design experiments, prioritize candidates for validation, and iterate rapidly between computation and the bench.%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Lead and mentor trainees and staff, set analytical standards, and help shape the scientific roadmap of the program.%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Communicate results through high-impact publications, presentations, and collaborations across UT Southwestern’s research and clinical community.%3C/p%3E%3Cp%3E%3Cstrong%3EAreas of focus%3C/strong%3E%3Cbr%3EDepending on your interests and strengths, your work can center on identifying novel cancer immunotherapy targets and/or developing novel therapeutics. Approaches may include:%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Machine learning applied to multi-omic, single-cell, and functional data%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Clinical–molecular correlations that link genotype and tumor biology to therapeutic response%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;De novo protein design%3Cbr%3E•%26nbsp;%26nbsp;%26nbsp;%26nbsp;Computational proteomics%3C/p%3E%3Cp%3E%3Cstrong%3EPreferred Qualifications%26nbsp;%3C/strong%3E%3Cbr%3E%3Cstrong%3EEducation%3C/strong%3E%3Cbr%3Eo%26nbsp;%26nbsp;%26nbsp;%26nbsp;Ph.D. in Bioinformatics, Computational Biology, Biomedical Engineering, or related field%3Cbr%3Eo%26nbsp;%26nbsp;%26nbsp;%26nbsp;Master’s degree in computer science, Electrical Engineering, or related field%26nbsp;%3Cbr%3E%3Cstrong%3EExperience%3C/strong%3E%3Cbr%3Eo%26nbsp;%26nbsp;%26nbsp;%26nbsp;2 years experience in driving computational biology/machine learning projects.%26nbsp;%3Cbr%3Eo%26nbsp;%26nbsp;%26nbsp;%26nbsp;4 years experience in driving computational biology/machine learning projects with Master%27s Degree.%26nbsp;%3Cbr%3Eo%26nbsp;%26nbsp;%26nbsp;%26nbsp;Post-doctoral fellowship preferred.%3Cbr%3E%26nbsp;%3C/p%3E%3Cp%3E%3Cstrong%3EBENEFITS%3C/strong%3E%3Cbr%3EUT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include:%3C/p%3E%3Cul%3E%3Cli%3EPPO medical plan, available day one at no cost for full-time employee-only coverage%3C/li%3E%3Cli%3E100% coverage for preventive healthcare-no copay%3C/li%3E%3Cli%3EPaid Time Off, available day one%3C/li%3E%3Cli%3ERetirement Programs through the Teacher Retirement System of Texas (TRS)%3C/li%3E%3Cli%3EPaid Parental Leave Benefit%3C/li%3E%3Cli%3EWellness programs%3C/li%3E%3Cli%3ETuition Reimbursement%3C/li%3E%3Cli%3EPublic Service Loan Forgiveness (PSLF) Qualified Employer%3C/li%3E%3Cli%3E%3Ca href=%22http://jobs.utsouthwestern.edu/benefits/#top%22 target=%22_blank%22%3ELearn more about these and other UTSW employee benefits!%3C/a%3E%3C/li%3E%3C/ul%3E%3Cp%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3EEXPERIENCE AND EDUCATION%3C/strong%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3ERequired%3C/strong%3E%3C/p%3E%3Cul%3E%3Cli%3E%3Cstrong%3EEducation%3C/strong%3E%3Cbr%3EPhD In Computer Science, Electrical Engineering, or related field or%26nbsp;%3Cbr%3EMaster%27s Degree In Computer Science, Electrical Engineering, or related field%26nbsp;%3Cbr%3E%26nbsp;%3C/li%3E%3C/ul%3E%3Cul%3E%3Cli%3E%3Cstrong%3EExperience%3C/strong%3E%3Cbr%3E2 years Experience in software development/engineering and/or HPC systems management with PhD. or%26nbsp;%3Cbr%3E4 years Experience in software development/engineering and/or HPC systems management with Master%27s Degree.%26nbsp;%3Cbr%3E%26nbsp;%3C/li%3E%3C/ul%3E%3Cp%3E%3Cbr%3E%3Cstrong%3EJOB DUTIES%3C/strong%3E%3C/p%3E%3Cul%3E%3Cli%3EDesigns and implements the high-performance scientific computing infrastructure for for large, multi-institution projects, including software applications, workflows, servers, databases, long-term and short-term storage solutions, and cloud services.%3C/li%3E%3Cli%3EServes as a domain expert for research and industry collaborations on biomedical computational methods, algorithms and platforms. Subject matter expert in multiple areas of computing technology.%3C/li%3E%3Cli%3ELeads and develops proof-of-concepts (PoCs) for solutions applied to biomedical and clinical science use-cases by working closely with industry collaborators.%3C/li%3E%3Cli%3EDesigns, develops, implements and optimizes algorithms and scientific workflows for high dimensional data in biomedical and clinical sciences.%3C/li%3E%3Cli%3EDevelops software and methods to explore, analyze and visualize biological data sets.%3C/li%3E%3Cli%3EDemonstrates and craft applications of cutting-edge visual computing technologies and connect them to core infrastructure.%3C/li%3E%3Cli%3EReport research results in journal articles, conference papers, and technical manuals.%3C/li%3E%3Cli%3EMentor and train staff, postdoctoral fellows, and graduate students.%3C/li%3E%3Cli%3ESupports faculty and students in adapting computational strategies to leverage high-performance computing, working with a range of systems and technologies such as compute cluster, parallel file systems, high speed interconnects, GPU-based computing and data servers.%3C/li%3E%3Cli%3EPerforms other duties as needed%3C/li%3E%3C/ul%3E%3Cp%3E%3Cstrong%3ESECURITY AND EEO STATEMENT%3C/strong%3E%3Cbr%3E%3Cbr%3E%3Cstrong%3ESecurity%3C/strong%3E%3Cbr%3EThis position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information. To the extent this position requires the holder to research, work on, or have access to critical infrastructure as defined in Section 117.001(2) of the Texas Business and Commerce Code, the ability to maintain the security or integrity of the critical infrastructure is a minimum qualification to be hired and to continue to be employed in the position.%3Cbr%3E%3Cbr%3E%3Cstrong%3EEEO%3C/strong%3E%3Cbr%3EUT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status.%3Cbr%3E%26nbsp;%3C/p%3E

Job Details
Primary Location: Texas-Dallas-5323 Harry Hines Blvd
Work Locations: 5323 Harry Hines Blvd, Dallas, 75390
Job: Professional & Executive
Organization: 371030 - SCC-Cell Therapy and CA Imm
Schedule: Full-time
Shift: Day Job
Employee Status: Regular
Job Type: Standard
Job Posting: Aug 13, 2026, 5:14:43 PM